Home / Small molecules / Discovery / Discovery Chemistry / Custom Chemistry
Custom Synthesis for Drug Discovery
You send the structure. We agree on the specification and deliver the compound.
Defined molecules, agreed specification
Custom synthesis sounds routine. The difficulty is in delivering it reliably, at scale, and on time. When a compound arrives late, off-spec, or short of the quantity you need, the program loses a month.
Fee-for-service works on a defined deliverable: structure, quantity, purity, date, agreed before the work starts. Scales run from milligrams to kilograms and the chemistry covers a broad spectrum of chemical matter.
Reagents and building blocks
Programs stall on materials as often as on chemistry. Our catalogue of research chemicals, reagents and building blocks is searchable through our extensive internal compounds catalog, and where a building block does not exist, we can make it — which is usually the faster answer for a building block that is heavily substituted, stereochemically defined or otherwise not held by a catalogue supplier.
What sits behind the synthesis
Analytical, purification, reagent and building-block resources sit alongside the synthetic teams rather than in a queue behind them. A compound that needs an unusual purification does not become a separate project with its own timeline, and a synthesis that needs an uncommon building block does not wait on procurement — in most cases we can make it.
When the molecule needs a specialist
Some molecule classes are not a question of capacity. Fluorination that will not go selectively, a ring that will not close, a lipid that will not purify. We run eight dedicated platforms for those, each staffed by chemists who work that class full-time.
The same route in, whether it is one compound or 400
Some molecule classes are not a question of capacity. Fluorination that will not go selectively, a ring that will not close, a lipid that will not purify. We run eight dedicated platforms for those, each staffed by chemists who work that class full-time.