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Flow Chemistry
A better route for chemistry that is hazardous, unselective, or simply impossible in batch.
Service highlights
- 120+ dedicated chemists and engineers at five sites: Shanghai, Tianjin, Wuhan, Chengdu and Nantong
- Full experience from parameter optimization to reaction up-scaling
- Reactions at scales from milligrams to kilograms
- Daily support to FTE and fee-for-service projects
- More than 100,000 flow reactions completed a year
- 15% of them reactions that are inaccessible in batch
- More than 80% focused on hazardous reactions
- Better than 90% success rate
- Kilogram-a-day output
- In-house designed and built flow automation
More than 30 reaction types
- Photochemistry
- Hydrogenation
- Metalation
- Nitration
- Diazotization
- Oxidation
- Reduction
- High temperature chemistry
Instruments
Vapourtec R series: flexible, precise and automatable, suited to medicinal chemistry and process research, with versatile pumps and a wide range of accessible reaction conditions. The platform is cited in more than 600 peer-reviewed publications with more than 400 installations worldwide.
Corning flow system: 1 to 5 kg production a day, with outstanding mixing and heat exchange, low internal volume, high residence time, and high chemical durability. Flow rate 5 to 50 mL/min, temperature from −60 to 200 °C, pressure to 1.8 MPa.
Oushisheng flow hydrogenation system: 2 to 5 kg production a day, temperature from room temperature to 200 °C, catalyst diameter 0.2 to 2 mm, flow rate 5 to 50 mL/min, pressure to 10 MPa.
From condition screening to scale-up
Condition screening runs in photo reactors, development on Vapourtec flow reactors, and scale-up on a 365 to 850 nm LED flow reactor.
The same platform continues into drug substance manufacture, so a flow step developed in discovery does not have to be re-established later.