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Steroid Chemistry
Full-stage support on a scaffold where the stereochemistry is the whole problem.
The platform
- More than 15 years of experience in steroid chemistry
- More than 100 dedicated steroid chemists
- More than 10,000 steroid compounds synthesized
- More than 20 chiral methods to build chiral centres on steroids
- More than 130 steroid starting materials in stock
- Process development and scale-up
Synthetic scale runs from milligrams to kilograms, covering development of novel cores for the A, B, C and D rings and side-chain functionalization.
Across the program
Hit to lead: new structure synthesis, new chemistry development, focused library production.
Lead optimization: fast delivery, route development, isotope labelling, absolute structure determination.
Drug candidate: large-scale synthesis, impurity synthesis, metabolite synthesis, process development.
Steroids in new modalities
The scaffold increasingly appears inside other modalities: targeted protein degraders with a steroid, antibody-drug conjugates with a steroid, and oligonucleotides with a steroid.