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Lipid Chemistry
The lipids and polymers a delivery system depends on, made where the payload is made.
The platform
- A dedicated team with specific skills in lipid chemistry
- More than 2,000 compounds delivered a year
- Better than 95% purity in lipids and polymers, using purification methods developed in-house
- Flexible service modes: FTE, fee-for-service or FIX
Lipid synthesis
- Synthetic scale from milligrams to hundreds of grams
- Better than 95% purity
- Ionizable lipids, neutral lipids, hybrid sterols, phospholipids, branched lipids and thio-derivatives
- More than 1,000 head and tail fragments readily available
Holding the fragments is what turns a structure-activity series around a lipid into an assembly exercise rather than a synthesis from scratch.
Polymer synthesis
- Synthetic scale from milligrams to grams
- Products validated by MALDI-TOF, NMR, GPC and LCMS
Integrated services
- Synthesis of known and novel lipids and polymers
- Synthesis of lipid or polymer helpers
- Condition screening and optimization
- Material for in vitro and in vivo research
- Ideas and solutions for specific delivery needs
Where the lipid is destined for a nanoparticle, the formulation and GMP manufacture sit in the same organization.
Lipid Nanoparticle
Chemistry Synthesis
We replace fragile bench routes with scalable chemistry, applying high-throughput screening, flow, and photoredox tools before scale-up issues become costly.
Discovery Chemistry
Integrated discovery chemistry to accelerate the early-stage development processes.