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Stable Isotope Labeling Chemistry
Including knowing where to put the label.
The platform
- Strong experience in non-radioactive isotopic labeling with deuterium, carbon-13 and nitrogen-15
- Experience in target design, synthesis and qualification
- Custom synthesis of stable isotope labeled targets, with an inventory of labeled starting materials and intermediates
- More than 100 stable isotope labeled projects completed in the past two years
- More than 2,000 labeled compounds delivered
- More than 200 labeled raw materials and building blocks in stock, to support quick delivery
Holding the labeled starting materials is why a labeled standard does not begin with a six-week procurement timeline.
How a labeling project runs
Labeling design: isotope selection, position selection, and three or more label types available — deuterium, carbon-13 and nitrogen-15. Position selection is part of the design service, not an instruction we wait for.
Route validation: route design, advanced intermediates, and incorporation of the isotope at the final step.
Labeling synthesis: isotope synthesis, with controls to ensure no deuterium-hydrogen exchange.
Material release: NMR to identify structure, HRMS to determine isotope percentage, HPLC for purity.
Where the labeled material is used
A labeled internal standard, a metabolite for a DMPK study, a tracer for a mass balance study — the labeled analogue and the unlabeled material come from the same chemistry and the same team.