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Biocatalysis
Enzymatic steps for the selectivity that chemistry struggles with.
The platform
Founded in 2016, the biotransformation platform provides high-throughput enzyme screening, process optimization and enzyme evolution development.
- More than 1,200 enzymes available in stock
- Strong technology support across detection, chiral resolution and process considerations
- A mature workflow with flexible service modes: FTE, fee-for-service and discovery process chemistry
- Experience in selective ester hydrolysis, asymmetric ketone reduction, asymmetric amine synthesis and asymmetric double bond reduction
- Capability from gram-scale reaction optimization to kilogram-scale production
Enzyme classes held
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Why screen rather than design
An enzyme that gives the right enantiomer on a model substrate frequently does not on the real one. With 1,200 enzymes on the shelf, finding the one that works is a screening exercise of days rather than an evolution campaign of months — and where no enzyme in the collection is good enough, evolution is the next step rather than the first.
The same enzyme at manufacturing scale
A biocatalytic step chosen in discovery carries through to drug substance manufacture on the same platform.